Project Leads:

Dr. Robert Everett & Dr. Li Wang

Co-investigators/Collaborators:

Melanie Basso and Jeffrey Bone

Project Description:

The current screening method for neonatal hyperbilirubinemia at BCWH is total serum bilirubin (TSB) tested in the laboratory. Although TSB is the most reliable method, it has several practical challenges (requires larger blood volumes, longer processing time, and consequently can impact discharge times)

A new and accurate alternate bilirubin measurement method by point-of-care instruments is under evaluation. Whole blood bilirubin (TwB) analyzed on a blood gas instrument requires a smaller sample of blood without sample processing and allows a faster turn-around time than conventional TSB measurement. This research will focus on the assessment of the clinical impact with TwB as a screening test in comparison to the TSB on the turn-around time of lab test results and the length of hospital stay at BCWH with a randomized controlled trial.

In addition to the assessment of clinical utility of whole blood bilirubin, this technology also has the capability of performing concurrent measurement of other analytes (blood gas, electrolytes, glucose, lactate, hemoglobin and co-oximetry), on the same sample of blood. This study will also evaluate the full panel to provide comprehensive assessment for neonates and infants admitted for care at BCW / BCCH.

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